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Sina Shahandeh , PhD

Chief AI Officer · CTO · Deep Tech Builder

Scaling Agentic AI, Multimodal Foundation Models & HPC/AI Infrastructure

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About

I build AI companies from zero to exit.

As a three-time founder/CTO, I've raised $8M+ and led teams through a $770M acquisition.

My PhD in high-performance computing (parallel systems, optimization) gives me deep architectural intuition for modern AI infrastructure. I've also governed AI strategy at the board level, including oversight of Canada's $375M national research and AI computing initiative.

My life project is to build a digital twin of the global economy, agent-based computational models where millions of simulated agents to replicate how real markets and societies function. I believe this will make humanity more rational, prosperous and empathetic.

I'm a hands-on technologist who speaks fluently to boards, investors, and engineers alike.

$8M+ Raised in Funding
$770M Exit/Acquisition
3× CTO Experience
$375M Board Oversight
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Experience

Startups & Venture Architecture

2022 – Present · Co-founding and hands-on executive leadership

RADiCAIT

CTO/CAIO
Boston, MA Aug 2024 – Present

A next-generation Generative AI platform in radiology generating in silico PET scans.

  • Imaging Foundation Models: Architected and shipped a proprietary GenAI imaging engine for cancer diagnosis on GPU clusters.
  • Venture Velocity: Launched in TechStars Boston, raised $1.5M pre-seed funding, among the top 20 companies at TechCrunch Disrupt 2025.
  • Regulatory Frameworks: Establishing the company's AI Governance framework for FDA approval and clinical deployment.

Gradient-Ascent

Principal AI Architect
Toronto (Remote) Mar 2024 – Aug 2024

Strategic advisor to Fortune 1000 executives on Enterprise AI Transformation and Agentic Architectures.

  • Productionizing Agentic AI: Designed and deployed autonomous AI Agents for complex enterprise workflows.
  • GenAI Strategy & Governance: Advised C-suite stakeholders on LLM adoption roadmaps and AI safety guardrails.

Ovom Care GmbH

Founding CTO
Berlin, Germany Feb 2023 – Mar 2024

Founding CTO at Merantix, Europe's premier AI Venture Studio. Led the 0-to-1 build of an AI-first fertility care platform.

  • AI-Native EMR: Built a proprietary Electronic Medical Record system for high-dimensional fertility data.
  • Fundraising: Partnered to raise $4M in VC capital and $1.5M in grants, achieving a $20M valuation within 12 months.
  • Clinical AI: Developed predictive AI models ensuring GDPR and medical device compliance.

Markets Replica – PlanWithFlow

Founder
Feb 2022 – Jan 2023

My passion project: pursuing the grand challenge of building an agent-based model of the economy, a digital twin where millions of computational agents replicate how real markets and societies function. Iterated through multiple experiments to bring this vision to market.

  • Agent-Based Modeling: Developed computational frameworks for large-scale economic simulation, inspired by breakthrough country-scale ABM research that outperforms traditional forecasting.
  • Product Experiments: Iterated from MarketsReplica.com through several pivots to a financial planning agent with early GPT-4 integration, among the first agentic AI applications PlanWithFlow.com.

Scale-Up Leadership & Exit Track Record

ecobee Acquired by Generac

Vice President of Data Science & AI
Toronto Dec 2018 – Jan 2022

Key executive driving the data and AI strategy that led to a $770M strategic exit/acquisition.

  • Organizational Scaling: Scaled the AI Center of Excellence from a boutique unit to 17+ researchers and engineers.
  • Edge AI Innovation: Led R&D in Deep Learning, Time-Series Forecasting, and Edge AI for millions of homes.
  • Strategic Leadership: Core member of executive leadership, defining the AI roadmap as primary valuation driver.

Board Memberships & Advisory

New Digital Research Infrastructure Organization of Canada

Board Director · 2020 – 2022

Oversaw a $375M initiative by the Ministry of Innovation, Science and Economic Development to architect Canada's national-scale digital research infrastructure and supercomputing capabilities.

Education

PhD

Computational Materials Science

The University of British Columbia, Vancouver 2007 – 2013

Developed high-performance computing (HPC) parallel codes and large-scale analytical tools for complex material systems. Applied first-principles modeling to solve high-dimensional optimization problems.

MSc

Materials Science and Engineering

Sharif University of Technology, Tehran 2004 – 2006

Finite element modeling and numerical optimization.

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Writings

Thoughts on AI, technology, startups, and building the future.

View All Writings →
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Get in Touch

I'm always interested in connecting with fellow technologists, founders, and anyone passionate about AI and deep tech.